When it comes to Main Comic, there are a number of synonyms that one can use to express the similar idea with different twists. Some of the common synonyms for the term include popular comic, lead comedian, primary humorist, star comedian, and headliner comic. Each of these synonyms highlights a different aspect of the Main Comic and can be used to draw attention to different elements of their performance. Whether one is describing a stand-up routine, a comedy movie, or a television show, there is always a variety of synonyms that can be employed to add complexity and nuance to one's language.