Antonyms for vindicate

prove one's innocence:

destroy, neglect, hurt, sentence, blame, disprove, oppose, desert, charge, forget, convict, incriminate, deny, attack, reject, ruin, prove, condemn, ignore, accuse, punish.

noun:

gainsay, impeach, question, refute, disprove, challenge, rebut, charge, convict, contradict, arraign, contest, dispute.